Publications
[2025]
1. Choi, S.; Kang, J.; Kim, J.-H. Alternative Splicing-Mediated Resistance to Antibody-Based Therapies: Mechanisms and Emerging Therapeutic Strategies. Int. J. Mol. Sci. 2025, 26, 11918.
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2. Hong S, Yu N, Cho JY, Lee GK, Ahn BC, Lee Y, Sim H, Song BR, Hwang M, Kim S, Kim JH*, Park C*, Han JY*. VEGF Signal Complexity Confers Resistance to Atezolizumab, Bevacizumab, Carboplatin, and Paclitaxel in EGFR-Tyrosine Kinase Inhibitor-Resistant Non-Small Cell Lung Cancer. MedComm. 2025 Aug 19;6(9):e70335. doi: 10.1002/mco2.70335. (*co-corresponding authors)
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3. Luo LZ, Kim JH, Herrera I, Wu S, Wu X, Park SS, Cho J, Cope L, Xian L, West BE, Calderon-Espinosa J, Kim J, Thompson Z, Maloo I, Larman T, Reddy KL, Feng Y, Fearon ER, Sears CL, Resar L. HMGA1 acts as an epigenetic gatekeeper of ASCL2 and Wnt signaling during colon tumorigenesis. J Clin Invest. 2025 Feb 3;135(3):e184442. doi: 10.1172/JCI184442.
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[2024]
4. Phillips JB, Park SS, Lin CH, Cho J, Lim S, Aurora R, Kim JH, Angajala A, Park B, Stone JK, Wang B, Kahn AG, Lim SS, Kim JH*, Ahn EE*, Tan M*. SON is an essential RNA splicing factor promoting ErbB2 and ErbB3 expression in breast cancer. Br J Cancer. 2024 Sep 23. doi: 10.1038/s41416-024-02853-x. (*co-corresponding authors)
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5. Vukadin L, Park B, Mohamed M, Li H, Elkholy A, Torrelli-Diljohn A, Kim JH, Jeong K, Murphy JM, Harvey CA, Dunlap S, Gehrs L, Lee H, Kim HG, Sah JP, Lee SN, Stanford D, Barrington RA, Foote JB, Sorace AG, Welner RS, Hildreth Iii BE, Lim SS, Ahn EE. A mouse model of Zhu-Tokita-Takenouchi-Kim syndrome reveals indispensable SON functions in organ development and hematopoiesis. JCI Insight. 2024 Jan 30:e175053. doi: 10.1172/jci.insight.175053.
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[2023]
6. Chia L*, Wang B*, Kim JH, Luo LZ, Shuai S, Herrera I, Chen SY, Li L, Xian L, Huso T, Heydarian M, Reddy K, Sung WJ, Ishiyama S, Guo G, Jaffee E, Zheng L, Cope LM, Gabrielson K, Wood L, Resar L. HMGA1 induces FGF19 to drive pancreatic carcinogenesis and stroma formation. J Clin Invest. 2023 Mar 15;133(6):e151601. doi: 10.1172/JCI151601.
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[2022]
7. Li L*, Kim JH*, Lu W, Williams DM, Kim J, Cope L, Rampal RK, Koche RP, Xian L, Luo LZ, Vasiljevic M, Matson DR, Zhao ZJ, Rogers O, Stubbs MC, Reddy K, Romero AR, Psaila B, Spivak JL, Moliterno AR, Resar LMS. HMGA1 chromatin regulators induce transcriptional networks involved in GATA2 and proliferation during MPN progression. Blood. 2022 May 5;139(18):2797-2815. (*co-first authors)
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[2021]
8. Jeong K*, Murphy JM*, Kim JH*, Campbell PM, Park H, Rodriguez YAR, Choi CS, Kim JS, Park S, Kim HJ, Scammell JG, Weber DS, Honkanen RE, Schlaepfer DD, Ahn EE, Lim SS. FAK Activation Promotes SMC Dedifferentiation via Increased DNA Methylation in Contractile Genes. Circ Res. 2021, Dec 3;129(12):e215-e233. (*co-first authors)
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9. Kim JH*, Jeong K*, Li J*, Murphy JM, Vukadin L, Stone JK, Richard A, Tran J, Gillespie GY, Flemington EK, Sobol RW, Lim SS, Ahn EE. SON drives oncogenic RNA splicing in glioblastoma by regulating PTBP1/PTBP2 switching and RBFOX2 activity. 2021, Nat Commun. Sep 21;12(1):5551. (*co-first authors)
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10. Dingemans AJM, Truijen KMG, Kim JH, Alaçam Z, Faivre L, Collins KM, Gerkes EH, van Haelst M, van de Laar IMBH, Lindstrom K, Nizon M, Pauling J, HeropolitaÅ„ska-Pliszka E, Plomp AS, Racine C, Sachdev R, Sinnema M, Skranes J, Veenstra-Knol HE, Verberne EA, Vulto-van Silfhout AT, Wilsterman MEF, Ahn EE, de Vries BBA, Vissers LELM. Establishing the phenotypic spectrum of ZTTK syndrome by analysis of 52 individuals with variants in SON. 2021, Eur J Hum Genet. Sep 15.
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11. Belmonte RL, Engbretson IL, Kim JH, Cajias I, Ahn EE, Stachura DL. son is necessary for proper vertebrate blood development. 2021, PLoS One. Feb 25;16(2):e0247489.
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12. Kim JH, Li L, Resar LM. Doubling up on function: dual-specificity tyrosine-regulated kinase 1A (DYRK1A) in B cell acute lymphoblastic leukemia. 2021, J Clin Invest. Jan 4;131(1):e142627..
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[~ 2020]
13. Vukadin L, Kim JH, Park EY, Stone JK, Ungerleider N, Baddoo MC, Kong HK, Richard A, Tran J, Giannini H, Flemington EK, Lim SS, Ahn EE. SON inhibits megakaryocytic differentiation via repressing RUNX1 and the megakaryocytic gene expression program in acute megakaryoblastic leukemia. 2020, Cancer Gene Ther. Nov 27.
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14. Stone JK, Kim JH, Vukadin L, Richard A, Lim ST, Tan M and Ahn EY. Hypoxia induces cancer cell-specific chromatin interactions and increases MALAT1 expression in breast cancer cells. 2019, JBC, Jul 19;294(29):11213-11224.
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15. Jeong K*, Kim JH*, Murphy JM*, Park H, Kim SJ, Rodriguez Y, Kong H, Choi C, Guan JL, Taylor JM, Lincoln TM, Gerthoffer WT, Kim JS, Ahn EE, Schlaepfer DD, Lim SS. Nuclear Focal Adhesion Kinase Controls Vascular Smooth Muscle Cell Proliferation and Neointimal Hyperplasia Through GATA4-mediated Cyclin D1 Transcription. 2019, Circ Res., Jul 5;125(2):152-166. (*co-first authors)
16. Murphy JM, Jeong K, Rodriguez YAR, Kim JH, Ahn EE, Lim SS. FAK and Pyk2 activity promote TNF-α and IL-1β-mediated pro-inflammatory gene expression and vascular inflammation. 2019, Sci Rep., 9(1):7617.
17. Kim JH, Park EY, Chitayat D, Stachura DL, Schaper J, Lindstrom K, Jewett T, Wieczorek D, Draaisma JM, Sinnema M, Hoeberigs C, Hempel M, Bachman KK, Seeley AH, Stone JK, Kong HK, Vukadin L, Richard A, Shinde DN, McWalter K, Si YC, Douglas G, Lim ST, Vissers LELM, Lemaire M, Ahn EE. SON haploinsufficiency causes impaired pre-mRNA splicing of CAKUT genes and heterogeneous renal phenotypes. 2019, Kidney International, pii: S0085-2538(19)30167-X.
18. Li J, Svilar D, McClellan S, Kim JH, Ahn EE, Vens C, Wilson DM, Sobol RW. DNA Repair Molecular Beacon assay: a platform for real-time functional analysis of cellular DNA repair capacity. 2018, Oncotarget, 9(60), 31719-31743
19. Hossain MK, Saha SK, Abdal Dayem A, Kim JH, Kim K, Yang GM, Choi HY, Cho SG. Bax Inhibitor-1 Acts as an Anti-Influenza Factor by Inhibiting ROS Mediated Cell Death and Augmenting Heme-Oxygenase 1 Expression in Influenza Virus Infected Cells. 2018, Int J Mol Sci, Mar 2;19(3)
20. Kim JH, Shinde DN, Reijnders MRF, Hauser NS, Belmonte RL, Wilson GR, Bosch DGM, Bubulya PA, Shashi V, Petrovski S, Stone JK, Park EY, Veltman JA, Sinnema M, Stumpel CTRM, Draaisma JM, Nicolai J, University of Washington Center for Mendelian Genomics, Yntema HG, Lindstrom K, de Vries BBA, Jewett T, Santoro SL, Vogt J, Deciphering Developmental Disorders Study, Bachman KK, Seeley AH, Krokosky A, Turner C, Rohena L, Hempel M, Kortüm F, Lessel D, Neu A, Strom TM, Wieczorek D, Bramswig N, Laccone FA, Behunova J, Rehder H, Gordon CT, Rio M, Romana S, Tang S, El-Khechen D, Cho MT, McWalter K, Douglas G, Baskin B, Begtrup A, Funari T, Schoch K, Stegmann APA, Stevens SJC, Zhang DE, Traver D, Yao X, MacArthur DG, Brunner HG, Mancini GM, Myers RM, Owen LB, Lim ST, Stachura DL, Vissers LELM, Ahn EY. De novo loss-of-function mutations in SON disrupt RNA-splicing of genes essential for brain development and metabolism, causing an intellectual disability syndrome. 2016, American Journal of Human Genetics, 99 (3), 711-9
21. Kim JH, Baddoo MC, Park EY, Stone JK, Park H, Butler TW, Huang G, Yan X, Behn FP, Myers RM, Tan M, Flemington EK, Lim ST, Ahn EY. SON and its alternatively spliced isoforms control MLL complex-mediated H3K4me3 and transcription of leukemia-associated genes. 2016, Molecular Cell, 61, 859–873
22. Kim JH, Ahn EY. Transcript variants of RUNX1T1: New insight into t(8;21)-positive leukemia. 2014, Leuk Res. 38 (9), 1018-1019.
23. Hossain MK, Choi HY, Hwang JS, Dayem AA, Kim JH, Kim YB, Poo H, Cho SG. Antiviral activity of 3,4'-dihydroxyflavone on influenza a virus. 2014, J Microbiol. 52 (6), 521-526.
24. Hickey CJ*, Kim JH*, Ahn EY. New discoveries of old SON: A link between RNA splicing and cancer. 2014, J Cell Biochem. 115 (2), 224-231. (*co-first authors)
25. Lee HJ, Cho ED, Lee KW, Kim JH, Cho SG and Lee SJ. Autophagic failure promotes the exocytosis and intercellular transfer of a-synuclein. 2013, Experimental & Molecular Medicine. 45 (e22): 1-9.
26. Jeon K, Lim H, Kim JH, Han D, Lee ER, Yang GM, Song MK, Kim JH, Cho SG. Bax Inhibitor-1 Enhances Survival and Neuronal Differentiation of Embryonic Stem Cells via Differential Regulation of Mitogen-Activated Protein Kinases Activities. 2012, Biochi. Biophy. Acta-Mol. Cell Res. 1823 (12): 2190-2200.
27. Kim JH, Song M, Kang GH, Lee ER, Choi HY, Lee C, Kim JH, Kim Y, Koo BN, and Cho SG. Combined treatment of 3-hydroxyflavone and imatinib mesylate increases apoptotic cell death of imatinib mesylate-resistant leukemia cells. 2012, Leukemia Research. 36 (9): 1157-1164
28. Jeon K, Lim HJ, Kim JH, Thuan N, Park SH, Lim YM, Choi HY, Lee ER, Kim JH, Lee MS, Cho SG. Differentiation and Transplantation of Functional Pancreatic Beta Cells Generated from Induced Pluripotent Stem Cells Derived from a Type 1 Diabetes Mouse Model. 2012, Stem cell and Dev. 21 (14): 2642-2655
29. Jeon K, Oh HJ, Lim H, Kim JH, Lee DH, Lee ER, Park BH, Cho SG. Self-renewal of embryonic stem cells through culture on nanopattern polydimethylsiloxane substrate. 2012, Biomaterials. 33 (21): 5206-5220
30. Kim JH, Lee ER, Jeon K, Choi HY, Lim H, Kim SJ, Chae HJ, Park SH, Kim S, Seo YR, Kim JH, Cho SG. Role of BI-1 (TEGT)-mediated ERK1/2 activation in mitochondria- mediated apoptosis and splenomegaly in BI-1 transgenic mice. 2012, Biochi. Biophy. Acta - Mol. Cell Res. 1823 (4): 876–888.
31. Lee CH*, Kim JH*, Lee HJ, Jeon K, Lim H, Choi HY, Lee ER, Park SH, Park JY, Hong S, Kim S, Cho SG. The generation of iPS cells using non-viral magnetic nanoparticle based transfection. 2011, Biomaterials. 32(28): 6683-6691. (*co-first authors)
32. Lee ER*, Kim JH*, Choi HY, Jeon K, and Cho SG. Cytoprotective effect of eriodictyol in UV-irradiated keratinocytes via phosphatase-dependent modulation of both the p38 MAPK and Akt signaling pathways. 2011, Cell. Physiol. Biochem. 27(5): 513-524. (*co-first authors)
33. Kwon JY*, Kim JH*, Jeong SW, Lee YS, Seo YR, and Cho SG. Effect of BI-1 overexpression on mitochondria in human fibrosarcoma cells. 2010, Korean Society for Cancer Prevention Research, 16 (1): 19-25. (*co-first authors)
34. Jeong HS, Choi HY, Lee ER, Kim JH, Jeon K, Lee HJ, and Cho SG. Involvement of caspase-9 activity in autophagy-medicated cell survival pathway. 2010, Biochi. Biophy. Acta-Mol. Cell Res. 1813 (2011) 80-90.
35. Jeong HS, Kim JH, Choi HY, Choi H, Lee HN, Lee ER, And Cho SG. Induction of cell growth arrest and apoptotic cell death in Human Breast Cancer MCF-7 Cells by FR122047. 2010, Oncol. Rep. 23:351-356.
36. Ahmed AD, Choi HY, Kim JH, and Cho SG. Role of oxidative stress in stem, cancer, and cancer stem cells. 2010, Cancers, 2:859-884.
37. Roh S, Choi HY, Park SK, Won C, Kim BW, Kim JH, Kang H, Lee ER and Cho SG. Porcine Nuclear Transfer Using the Somatic Donor Cells Altered to Express Male Germ Cell Function. 2009. Reproduction, Fertility and Development. 21:882-891
38. Kang GY, Lee ER, Kim JH, Jung JW, Lim J, Kim SK, Cho SG, Kim KP. Downregulation of PLK-1 expression in kaempferol-induced apoptosis of MCF-7 Cells. 2009, European Journal of Pharmacology. 611(1-3):17-21
39. Jeong HS, Choi HY, Choi TW, Kim BW, Kim JH, Lee ER, and Cho SG. Differential regulation of the anti-apoptotic action of B-cell lymphoma 2 (Bcl-2) and B-cell lymphoma extra long (Bcl-xL) by c-Jun N-terminal protein kinase (JNK) 1-involved pathway in neuroglioma cells. 2008, Biol Pharm Bull. 31 (9): 1686-1690
40. Kim BW, Lee ER, Min HM, Jeong HS, Ahn JY, Kim JH, Choi HY, Choi H, Kim EY, Park SP, Cho SG. Sustained ERK Activation is Involved in the Kaempferol-Induced Apoptosis of Breast Cancer Cells and is More Evident under 3-D Culture Condition. 2008, Cancer Biol. Ther. 7(7): 1080-1089
41. Lee ER, Kang YJ, Kim HJ, Choi HY, Kang GH, Kim JH, Kim BW, Jeong HS, Park YS, and Cho SG. Regulation of apoptosis by modified naringenin derivatives in human colorectal carcinoma RKO cells. 2008, J. Cell. Biochem. 104(1):259-273.
42. Lee ER, Yong-Jin Kang, Choi HY, Kang GH, Kim JH, Kim BW, Han YS, Nah SY, Paik HD, Park YS and Cho SG. Induction of apoptotic cell death by synthetic naringenin derivatives in human lung epithelial carcinoma A549 cells. 2007, Biol. Pharm. Bull. 30(12):2394-2398.
43. Lee ER, Kim JH, Kang YJ, and Cho SG. The anti-apoptotic effect of eriodictyol on the UV-induced cell death of keratinocytes. 2007, Biol. Pharm. Bull., 30(1):32-37.
44. Lee ER, Kim JY, Kang YJ, Ahn JY, Kim JH, Kim BW, Choi HY, Jeong MY, Cho SG. Interplay between PI3K/Akt and MAPK signaling pathways in DNA-damaging drug-induced apoptosis. 2006, Biochim. Biophys. Acta., 1763(9):958-68.
45. Lee ER, Kang YJ, Kim JH, Lee HT, Cho SG. Modulation of apoptosis in HaCaT keratinocytes via differential regulation of ERK signaling pathway by flavonoids. 2005, J. Biol. Chem., 280(36):31498-507.